17/07/21 – Sportlust’46 2-0 SV Spakenburg
24/07/21 – RKVV Westlandia 1-3 R. Cappellen FC
03/09/21 – Feyenoord (vr.) 2-2 SC Heerenveen (vr.)
04/09/21 – Bonner SC 1-2 Wuppertaler SV
04/09/21 – RC Hades 2-1 K. Sporting Hasselt
18/09/21 – VV Hardinxveld 8-0 SV Capelle
18/09/21 – Patro Eisden Maasmechelen 0-0 KVV Thes Sport
25/09/21 – Go-Ahead Kampen 4-0 DOS Kampen
02/10/21 – NIVO-Sparta 1-1 WNC Waardenburg
02/10/21 – K. Lyra-Lierse 3-1 Eendracht Aalst
10/10/21 – OFC Oostzaan 3-1 RKVV DEM
16/10/21 – R. Excelsior Virton 2-1 Lierse K.
24/10/21 – Stade de Reims 1-2 ESTAC Troyes
26/10/21 – ASWH 1-3 Heracles Almelo
27/10/21 – GVVV 0-2 Sparta Rotterdam
06/11/21 – ODIN’59 1-1 VV Ter Leede
06/11/21 – Amsterdamsche FC 5-1 SV Spakenburg
07/11/21 – VPV Purmersteijn 4-1 VV De Zouaven
19/11/21 – Hannover 96 0-0 SC Paderborn 07
20/11/21 – Eintracht Braunschweig 2-0 Türkgücü München
20/11/21 – Hannover 96 II 1-2 SV Werder Bremen II
21/11/21 – 1. FC Lokomotive Leipzig 1-0 BSG Chemie Leipzig
04/12/21 – AS Roma 0-3 Inter Milano
18/12/21 – K. Sporting Hasselt 2-2 RC Hades
05/02/22 – KRC Gent 0-2 KRC Harelbeke
19/02/22 – KOSC Wijgmaal 0-1 K. Londerzeel SK
25/02/22 – KVV Thes Sport 1-1 Patro Eisden Maasmechelen
26/02/22 – VV Wieldrecht 0-2 EBOH
01/03/22 – VV Nieuw-Lekkerland 0-1 VV Kloetinge
02/03/22 – Club Brugge KV 0-3 KAA Gent
05/03/22 – VV Terneuzense Boys 0-0 VV Kloetinge
10/03/22 – Vitesse 0-1 AS Roma
12/03/22 – SV Huizen 1-1 HSV De Zuidvogels
17/03/22 – Feyenoord 3-1 FK Partizan
20/03/22 – VV Hillegersberg 1-3 DHC Delft
25/03/22 – Malta 1-0 Azerbeidzjan
01/04/22 – Woodford Town FC 0-1 Newham Athletic FC
02/04/22 – Luton Town FC 2-2 Millwall FC
03/04/22 – West Ham United FC 2-1 Everton FC
03/04/22 – Chelsea FC (v) 5-0 Reading FC (v)
04/04/22 – Crystal Palace FC 3-0 Arsenal FC
23/04/22 – VV Papendrecht 0-1 VV Brielle
28/04/22 – Feyenoord 3-2 Olympique Marseille
29/04/22 – FC Dordrecht 3-2 FC Volendam
30/04/22 – VDL-Maassluis 0-1 MVV’27
11/05/22 – Sparta Rotterdam 2-0 PEC Zwolle
13/05/22 – FK Mladá Boleslav 2-2 SK Sigma Olomouc
14/05/22 – SK Mondi Štětí 3-0 FK Neratovice-Byškovice
14/05/22 – FK Litoměřicko 2-0 FK ASK Lovosice
14/05/22 – Bohemians Praha 1905 4-0 MFK Karviná
15/05/22 – Bohemians Praha II 3-4 FK Sokol Živanice
15/05/22 – SK Slavia Praha 1-2 AC Sparta Praha
29/05/22 – VV Virtus 3-4 SC Gastel
12/06/22 – HVV 1-0 SV KDO
15/06/22 – HSC’21 1-3 GVVV
18/06/22 – SV Nootdorp 3-1 SDC Putten
21/06/22 – FC Oudewater 3-1 VV Rozenburg
22/06/22 – Kozakken Boys 3-1 GVVV
25/06/22 – SDV Barneveld 1-0 SV Nootdorp
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